It’s taken me some time and a lot of web pages which tried to solve the readline support with all kinds of hacks, but finally I’ve been able to get readline support and auto-completion for IPython to work. As it can be quite confusing and hard to follow all posts, this will be a step-by-step approach to get things to work. Note that I’ve got it working on Mac OS X 10.5.7 Leopard. It is expected to work on Leopard at least. Other versions might not require the exact same solution.